Both the teams have won their respective opening matches with Germany getting past Costa Rica 2-1 and Iran beating Guinea 3-1 last Saturday.
Real Madrid have avoided defeat in their last 41 LaLiga games, the second best streak by a team in the competition's history.
Captain and star striker Jann-Fiete Arp (7th and 65th) struck twice while Yann Bisseck (39th) and John Yeboah (49th) scored a goal each to help Germany reach the quarters.
The football fans in Kochi will get a chance to witness a fascinating contest between Brazilian attacking flare and Spanish 'tiki-taka' possession football in what could be a final before the final of this tournament.
European champions Spain produced a quality exhibition of tiki-taka as they decimated Iran 3-1 to reach the semi-finals of the FIFA Under-17 World Cup, at the Jawaharlal Nehru stadium in Kochi, on Sunday.
Jan-Fiete Arp (8th minute), Nicolas Kuehn (62nd) and Sahverdi Cetin (90+2) netted for the winners, while Ibrahima Soumah got the lone goal for Guinea in the 26th minute in the final Group C match at the Jawaharlal Nehru International Stadium.
A dominant Brazil made a strong statement of their top title contender status with a 2-1 victory over Spain in a Group D marquee clash of the FIFA U-17 World Cup, in Kochi, on Saturday.
